Introduction

Under Development

MyoScore is currently under active development and not yet publicly available.

MyoScore (Genetic Muscle Health Score, GMHS) is a transcriptome-based quantitative assessment system for muscle health.

Overview

GMHS integrates GWAS-TWAS analysis with multi-cohort RNA-seq data to construct an objective myopathy severity score. It quantifies muscle health on a 0-100 scale across five genetically-driven dimensions.

Five Dimensions

Dimension	Weight	GWAS Source	Meaning
Strength	25.2%	Grip strength, walking pace	Muscle function
Mass	17.7%	Fat-free mass (whole body, appendicular)	Muscle mass
LeanMuscle	24.3%	Thigh fat infiltration MRI	Low fat = healthy
Youth	24.2%	Telomere length	Biological age
Resilience	8.7%	Myopathy diagnosis, CK levels	Disease resistance

Score interpretation: Higher score = Healthier muscle

Citation

Revealing myopathy spectrum: integrating transcriptional and clinical features of human skeletal muscles with varying health conditions. Communications Biology, 2024.