MyoPath

Under Development

MyoPath is currently under active development and not yet publicly available.

MyoPath is an automated skeletal muscle pathology analysis tool for HE-stained whole slide images (WSI).

Overview

MyoPath provides quantitative assessment of muscle pathology from HE-stained biopsy sections, extracting key histopathological features that characterize neuromuscular disease severity.

Key Features

• Fat infiltration quantification
• Fibrosis area estimation
• Muscle fiber morphometry (diameter, cross-sectional area, coefficient of variation)
• Inflammatory infiltrate detection
• Automated whole slide image processing

Clinical Relevance

MyoPath pathology metrics correlate with MyoScore's transcriptomic dimensions:

• LeanMuscle dimension ↔ Fat infiltration (negative correlation)
• Youth dimension ↔ Fibrosis extent (negative correlation)
• GMHS composite ↔ Fiber coefficient of variation (negative correlation)

Citation

Revealing myopathy spectrum: integrating transcriptional and clinical features of human skeletal muscles with varying health conditions. Communications Biology, 2024.